After a marshal and deputy are wounded and killed, Gil and Rowdy volunteer to finish the delivery of the prison wagon with seven dangerous prisoners to Ft Craig for trial, while the outlaw husband of one prisoner is in pursuit to free her.
Rowdy's wartime friend, they spent time in a POW camp, is getting married. The bride's stepbrother, a murderer sixteen times over, has returned to claim his share of the family fortune.
A stage load of passengers being chased by the man with the black satchel wrecks. Favor takes them to his camp. The man is a hired executioner after someone from the stage or the herd.
Rowdy tries to help Clovis leave her sheriff husband.
A fanatical Southern loyalist lures drovers from Favor and Rowdy with tales of founding a new Confederate empire; guest Lon Chaney Jr.
Gil Favor gets permission from rancher Jed Reston to drive his herd over Reston's land. He discovers, however, that Reston has a bigoted attitude toward Indians, particularly a local Comanche named Taslatch who wants to be a farmer and who's paid for a mail-order plow. (Reston's recently had his son, Matt, give Taslatch 15 lashes on a trumped-up rustling charge.) Favor earns Reston's enmity by siding with Taslatch. Tensions soon escalate until violence is set to erupt between the Comanches and local townspeople and Favor must take decisive steps to intervene.
Brazo, a retired gunfighter, attempts to keep his kid brother from taking up the family business.
Four stranded women provide a love interest and a complication for Favor. A freight hauler with a gunfighter says he's using the only river crossing first.
When Rowdy and two steers are thought to have anthrax, The only medical help is a young lady with two years of nursing school. Her town doesn't want anything to do with the drovers or the herd.
Brother Bent the newest drover sparks gold fever, when he flashes a huge nuggett.
Banditos inside and outside threaten the herd and the drovers.
The drive faces a formidable tasks climbing to a plateau known for it's high winds and dust storms. Favor hires Tom Bryan more for his wagon than the man. Tom sneaks a woman dressed in a bridal gown into the wagon. Jefferson Devereaux, a wealthy land owner, comes looking for a man and a woman, his wife, Jenny. Rowdy was a POW with Tom. He says Tom sold out. Jeff and forty men will be back in the morning for Tom and Jenny.
Favor and Rowdy are looking for strays. They enter a deserted mining town. Matt Lucas is the caretaker. He says he's the only one there. Leaving they hear an organ. Mrs. Miller and her daughter, Angie, say Lucas and his son, Waldo, gunned down the stage coach driver, and is holding them hostage.
Favor stops Talby from shooting Johnny Camber, who he says is Billy Carter, who killed his daughter. Clark accuses Carl Myers of being a trail camp thief and a card cheat. Favor decides to take the herd across the dry plain at the worst time of the year. The men begin to question Favor's judgment. Eventually all but six of his men quit.
Favor and Pete find Jenny Watson outside a burned cabin. Her parents who died of a sickness were burned with the cabin. Favor invites Jenny to ride along to Silver Junction. Jenny is in cahoots with three brothers to rob Favor of the drive's payroll.
Rowdy finds two indians dead outside a house. Amelia Spaulding is inside singing and making candy.
Pete is injured, so Favor and Rowdy into a nearby town for a doctor. Because the town lynched a man the day before, the residents along with Favor and Rowdy are held hostage until the Sheriff and the man who led the lynching are also hung.
Favor's welcome to Paradise Valley is a group of gun toting farmers warning the herd better not do any damage to their property. Lightning stampedes the remuda and kills farmer Ken Wade. His wife urges Eli to avenge her husband's death.
Jess Hode, a bitter ex-trailboss who the owners thought was too old, demands half of Favor's herd for the only water around. Jess' son stands by him but soon comes to see through his old man. Favor tries a couple other water holes but they are dry.
With wolves threatening the herd, Pete is sent to town to get a wolver and traps. None are available, but he meets his old flame, Nora Sage. She is later found strangled in her room. Brad Morgan, Medrina Wilcox's foreman also came to see her. Medrina has a herd but only one man. They pool herds. Brad was a wolver, and directs Favor's men in placing the traps. Brad toys with the affections of Nora, Medrina and her sister Paula. Favor lets the sheriff take Pete, but says he needs Morgan.
Favor and Rowdy ride into a settlement of women to find out the source of explosions threatening to stampede the herd. They're told to go to the camp. It uses contract prison labor. The women are the wives and girlfriends of the convicts. Todd McCauley has one month to go, but Clement won't release him saying he knows where the money he stole is. Todd arranges a breakout. The convicts need horses and head for the drive.
A badly beaten wild man, Bing, says that Comancheros are planning to take the herd. Rowdy befriends a woman, once a countess, now being held by the Comancheros. She offers a mirror for the kindness Rowdy has shown. Rowdy says he couldn't accept it. She sneaks it into his saddlebag. At a trading post the mirror is identified as one taken in a Comanche raid. Rowdy is thought to be a Comanchero and has to fight his way out. Rowdy goes to the Comanchero camp to get Louisa to back up his story and is caught. Loouisa tells Rowdy of the Comancheros plans. Bing was sent by the Comancheros to lead the drive to them.