After being on her own for some time, Meredith is beginning to explore the idea of a romance with Riggs. Unfortunately, Maggie desires him as well, which threatens to drive a bitter wedge between the sisters. At the same time, despite their differences, Jackson and April must come together when they are assigned a difficult case. Meanwhile, Alex faces the consequences of his vicious attack on DeLuca, Owen and Amelia's marriage implodes and a hospital-wide mutiny erupts when Bailey demotes Webber. Finally, Arizona may have found love again - but is she sleeping with the enemy?
When one of Grey Sloan’s own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help. Meredith juggles huge secrets that affect her relationships with Alex and Maggie. While Richard helps Jo with a big decision, April and Catherine clash over the new baby.
Meredith considers her loyalties, as Alex deals with the repercussions of his actions. Newlyweds Amelia and Owen host a dinner party with unlikely guests, and Jackson proposes an arrangement to help April through her recovery.
A car crash at a funeral brings a bickering family into the hospital. Back from New York, Arizona ends up caught between Alex and Andrew. While Ben takes on a new parenting role, Amelia helps Meredith and Maggie through a problem.
Alex tries to do the right thing but still cant catch a break. Jackson and April adjust to their “new normal” with the baby. While Meredith and Nathan establish what’s going on between them, Amelia questions the state of her relationship with Owen.
Meredith and Bailey are at odds when both of their patients need a liver transplant, Owen seeks help from the other doctors when he is charged with babysitting baby Harriet for the day, and Amelia struggles with telling Owen some important news.
A familiar face returns to Grey Sloan, throwing many of the doctors for a loop. With Catherine putting on the pressure, Bailey has to make a decision about Alex while a tough ER case makes Amelia’s bad day even worse.
The arrival of a new consultant puts all of the doctors on edge, especially once she starts stepping on toes in the OR. Amelia and Owen bring their personal problems into the hospital, while April explores some uncharted territory.
A difficult surgery brings back pivotal memories for Meredith, Richard, Owen and Stephanie, as they work together to save a life.
Believing he is going to jail tomorrow, Alex makes a big decision about his future. While the hospital is overrun with victims of a building collapse, Richard demands answers from Bailey about Eliza’s presence at Grey Sloan.
Bailey, Arizona and Jo go to a maximum security women’s prison to treat a violent, 16-year-old pregnant girl and her unborn baby.
Richard and the attendings set out to make Eliza’s first day at Grey Sloan a bumpy one. Meanwhile, Meredith tries to track down Alex.
Maggie gets a surprise visit from her mother at the hospital. Bailey has to make a difficult decision when one of the attendings refuses to work with Eliza, and Stephanie gets caught up in Owen and Amelia’s personal drama.
The residents are excited for Eliza’s next phase of teaching, but they spend the day caught between the warring attendings. Meanwhile, April has a challenging first day in her new role at the hospital.
Alex returns to the hospital and discovers a lot has changed since he left. Meanwhile, Jo has to make a difficult decision on a case, and Arizona tries to distance herself from Eliza.
Richard, Jackson, April and Catherine tackle a grueling trauma case intensified by hospital politics. Amelia finally faces her feelings about Owen, and Meredith gets caught between Nathan and Alex over a patient.
Jackson and April travel to Montana in order to perform a complicated surgery on a young patient, but Jackson’s mind is elsewhere, and April is forced to step up and get him back on track.
Diane Pierce returns to Grey Sloan, but Maggie is still in the dark as to why she’s really there. Owen and Amelia hash out their problems as they work a trauma case together, and Bailey tries to mend her relationship with Richard.
When Maggie’s mom’s health deteriorates, the doctors are at odds over how to treat her. Meanwhile, Richard comes to grips with Bailey’s betrayal over the Residency Program.
When Maggie takes on a big case, many of the doctors are worried she’s not the right one for the job while Stephanie makes a mistake treating one of Grey Sloan’s own.
Meredith and Nathan have to confront their feelings when they are are stuck sitting next to each other on a plane.
Bailey and April work to fix things between Richard and Catherine; Eliza continues to pursue Arizona; one of Alex's previous patients returns to Grey Sloan.
April and Andrew consult with a fiery patient who has a giant, inoperable heart tumor. Meanwhile, Alex and Eliza are at odds over the treatment of a young patient, and Stephanie and Ben make decisions that could affect their careers.
The doctors of Grey Sloan encounter a difficult case involving a dangerous patient. Meanwhile, Owen receives life-changing news that pushes Amelia to step up to support him, and Alex attends a medical conference after making a shocking discovery.
The doctors’ lives are at risk after a dangerous patient escapes the hospital room. Alex must make a hard choice in his relationship with Jo while Meredith has some big news for Nathan that brings things to a turning point.