Jay and Gloria are navigating life with their youngest son, Joe, while Manny has headed off to college to explore the world on his own terms. Meanwhile, Claire and Phil have officially lost their status as empty-nesters when Haley started her own family and moved back home with her new husband, Dylan, and a set of twins. Luke, is now looking to his next move; and Alex is learning how to balance life outside of academia. Then there's Mitchell and Cameron, who are still working to understand their gifted teenage daughter, Lily, and juggle busy careers.
Haley is determined to follow the advice in her parenting books with the twins, but Phil and Claire think their old methods are better. Meanwhile, Manny is set to direct Jay’s dog bed commercial in the hopes of winning his ex-girlfriend back.
Claire needs to get everyone out of the house before they make her look bad in front of a reporter from an important women's business magazine. Meanwhile, Jay invites Manny to a little wine tasting in an attempt to spend some quality time together.
Phil, Claire, Alex and Luke love having the twins around, but taking care of them is exhausting! However, when they realize the babies might help them with a few things on their to-do lists, they offer to give Haley the day off.
Mitch and Cam help Lily overcome her insecurities about wearing a bathing suit to a pool party but discover their own. Meanwhile, now that Gloria's new internship is taking up so much of her time, Jay is feeling particularly neglected.
Phil is determined to finally scare Claire on Halloween. Meanwhile, for the first time, Gloria is feeling self-conscious about her age when someone correctly assumes she is Jay's wife; and Mitch and Cam head to the WeHo Halloween Carnival after Lily decides to go to her first Halloween party alone.
Gloria is using her alone time with the twins as an opportunity to secretly baptize them before Haley and Dylan get home. Meanwhile, Claire is still dealing with the fallout from the smart closet fiasco, and Cam is at war with his school's mascot who is threatening his chance at securing a new college coaching job.
Cameron and Mitchell's friends mistakenly assume they have split up and have definitely chosen a side, and Haley attempts to cook Thanksgiving dinner as a thank you for Claire and Phil's support with the twins. Meanwhile, Jay invites Phil and Dylan out to fly his model plane, and Phil thinks this is his chance to reclaim his dignity after their first outing 10 years ago went so wrong.
The Dunphy house is bursting at the seams when Dylan's hippie mom moves in and Claire's lonely stepdad, Jerry, wants to pay them a visit. Meanwhile, Jay and Gloria attempt to help Manny get over his big breakup with Sherry.
Cameron is hoping to keep everyone happy for their annual Christmas dinner as he hides and prepares for his big interview for a head coaching position out-of-state. Meanwhile, Haley is excited to be finally be reunited with wine and Mitchell is suspicious of Cam’s holiday trip to visit his family in Missouri.
Alex's new company is putting her up at a new luxury apartment with full amenities and a list of high-profile residents that the family is eager to take advantage of, without her knowing. Phil is on a mission to review the restaurant's famous sliders for his food blog, while Mitch and Cam sneak in separately to meet its most famous resident, David Beckham. Meanwhile, Luke and Manny head straight for the gym to try and pick up on older women and end up in some hot water with a few of the residents.
Phil pays a visit to his dad to make sure he is ok after hearing some concerning news about him. Meanwhile, Jay gives Claire and Mitch a bunch of their old childhood memorabilia that triggers them to reevaluate a long-held story about their first family vacation.
Mitchell learns a valuable life lesson when Murray, a former resident of the house, shows up unexpectedly. Meanwhile, the Dunphy's old neighbor-turned-tech-titan, Kenneth, comes to visit with a big surprise for Phil. Then, Manny's dad, Javier, shows up with a big opportunity for his son.
In one last family trip, the Pritchett-Dunphy-Tucker clan heads to Paris so Jay can accept a lifetime achievement award for his work in the closet industry. However, his old nemesis, Earl Chambers, finds a way to haunt him. Meanwhile, Claire has a secret rendezvous in one of the most romantic cities in the world, and Cam's lifelong dream of performing as Fizbo on the streets of Paris is about to become a reality.
Phil and Claire take Haley and Dylan to dinner to reassure them they are not bad parents. While out to dinner, they run into Mitch and Cam who are chaperoning Lily's first date, as well as Jay and Gloria after attending Joe's school play.
Claire has landed an interview for her dream job and is thwarted on her way to the interview by Phil's tricky staircase. Meanwhile, Cam and Mitch debate the pros and cons of adopting another baby after unexpectedly receiving a call from their adoption agency.
Mitchell is having a hard time letting go of his old life and Gloria steps in to help him say goodbye. Meanwhile, Haley, Luke and Alex decide to throw a party at the Dunphy house when Claire and Phil leave for a trip, and Dylan's mom takes the twins for the night.
Mitchell and Cam settle in on their new normal, and Phil and Claire decide that one of the kids needs to move out in order to take control of the house again. Meanwhile, as Gloria becomes more successful at work, she notices Jay, Manny and Joe don't seem to need her as much.
The entire family discovers saying goodbye is much harder than it seems.