After three months and ten worlds of searching for Wade and Rembrandt, Quinn and Maggie finally reach Earth Prime, only to find it under Kromagg control. Quinn and Maggie manage to rescue Rembrandt from a Kromagg prison, but Quinn is captured and learns the shocking truth about his family.
Quinn, Rembrandt and Maggie land on a world where the United States is run by the Oracle, a blend of fundamental beliefs and right-wing conservatism. Followers trade their wealth and possessions in return for passage to a nirvana world, but the Sliders discover the Oracle's portal is a deadly sham.
The Sliders slide into a Kromagg weapons-testing area and Maggie saves the life of the Kromagg commander, Kromanus. While Maggie tries to get the timer back from him, Quinn and Rembrandt discover a Kromagg weapon designed to eradicate humans.
The Sliders arrive on a world where virtual reality is a normal part of life. After Maggie is injured in an explosion, she awakens in a hospital to find they have missed the slide. The only way to go is to build a new timer, but is everything what it seems?
After landing in a San Francisco completely devoid of people, the Sliders go to Quinn's house and discover Quinn's double accidentally slid everyone to a parallel world a few years ago. Both Quinns, Maggie and Rembrandt travel to the world where everyone was sent and rush to set things right.
The Sliders track down Quinn's long lost brother, Colin, to a Amish-type Earth. Quinn convinces Colin they are brothers and to slide to find their true home. But on the next world, a double of Colin's former love takes advantage of him and involves him in a scam to steal cryogenically frozen bodies.
On a world where drug use is mandatory, Maggie and Colin are dosed with mind-altering chemicals. Rembrandt and Quinn have to find a way to save them and outrun the Drug Empowerment Administration.
Acid rain forces the Sliders to stay in the Chandler Hotel. Colin claims to have seen a ghost and the timer is mysteriously stolen.
When Quinn and Colin finally access the coordinates to their home, the Sliders expect it to be their last slide. Instead, they arrive inside a security compound on a barren world, where humans and Kromaggs are fighting for survival.
On a world raided by Kromaggs for natural resources, Rembrandt falls in love with a doctor who can save a critically injured Quinn. Problem is, Maggie learns this doctor collaborated with the Kromaggs and is on the run from the British secret service.
The Sliders land on a world where California has been taken over by racists. Rembrandt is captured and placed in a prison camp used to turn non-whites into faceless slaves.
The Sliders arrive on a Kromagg training camp, where half-human Kromaggs hunt humans. Quinn tries to convince one of them to help free a captured Colin.
The vortex splits the Sliders up and they only have two hours before the slide. Quinn tries to contact the others by appearing on the world's most popular show: Lipschitz Live. Meanwhile, Colin is mistaken for his double and betrothed to a woman as part of a business deal.
The Sliders discover a woman escaping from a Kromagg breeder camp and take her to her Earth, where an anti-Kromagg virus proves deadly for her half-Kromagg son.
A sliding mishap separates the Sliders into two groups on a world divided by the computer-savvy and ruthless scavengers. To reunite, they'll have to battle the scavengers and unite a young couple who fell in love on the internet.
The Sliders accidentally slide out with Maggie's double, leaving Maggie stranded on an American military base where deadly experiments are performed on pilots. Meanwhile, the Sliders arrive on a world that outlaws technology.
When the Sliders step into the Chandler Hotel, they are surprised to learn they have been turned into computer data. There they meet the owner of the hotel, Archibald Chandler, who will not allow them to leave.
Colin is wounded on a Wild West Earth and separated from the others. While he is nursed back to health by a widow and her daughter, the others search for him and find an old foe.
The Sliders arrive on a world where clones are harvested for spare body parts. Quinn's double is blinded in a lab accident and when Quinn tries to help, he is mistaken for a clone. Meanwhile, the others inadvertently rescue the clone, which Colin tries to teach the importance of family and sacrifice.
The Sliders arrive in what is literally the happiest place on Earth. But in this small community, a little girl witnessed her grandfather leap into a mysterious chasm and begins to feel an overwhelming sorrow. Worse yet, it soon spreads to Rembrandt and Maggie.
A rough slide separates Quinn and Maggie from Rembrandt and Colin for a brief time. Soon after they reunite, Quinn and Maggie become seriously ill and appear to be dying of old age. Unable to help them themselves, Rembrandt and Colin will have to rely on someone claiming to be Quinn and Maggie's son.
With nearly a month until their next slide, the Sliders find themselves extremely bored on a dull world. While the others get jobs, Rembrandt dives into a sci-fi book that bears more than a resemblance to their lives. When the Sliders track down the author, they learn he came from Quinn and Colin's home world.