Allison and her family deal with the outcome of her brain surgery and its possible lasting effects. Also, a local television station owner asks Devalos and Scanlon to look into the possible stalking of his sportscaster, who is also his wife.
When Ariel acts strangely, Allison becomes worried that her daughter might be possessed with the spirit of a murdered stripper who wants revenge on her killer.
When Allison's friend with cancer suddenly dies she suspects a hospital employee may be at fault. Meanwhile, Bridgette writes a story that closely follows what later happens at Joe's job interview.
Allison believes she is having after effects from her recent brain surgery after experiencing strange symbols as visions. However, as the story plays out, it seems the symbols may be the key to uncovering the true identity of a serial killer.
On the 100th episode of Medium, an infant is kidnapped and Allison investigates the disappearance. But when she becomes too obsessed with the infant, Joe starts to get worried about her. Meanwhile, Bridgette and Joe are surprised after Marie manages to play the clarinet without any issues even though she hasn't attended any classes, while Bridgette is struggling to play.
The film "Night of the Living Dead" gets Allison nightmares where scenes from the movie are put in her mind. It results in her getting cuts and bite marks and even clues that lead to hear funeral director's killer.
When Allison's car is wrecked, the SUV she rents turns out to have some unusual features, including a satellite radio that allows her to hear other people's conversations.
Allison fears the worst about Ariel's new boyfriend when she suspects him of murdering a man. Also, Bridgette posts embarrassing videos of a man on the Internet and gets into trouble.
Odd things occur for Allison, starting with her new sensitivity to light and the fact that the sunglasses she wears shows mysterious numbers that can tie into people's life expectancies. Like that wasn't enough, Allison has a dream about Joe's dad, causing Joe to begin taking better care of his health.
Samples of a lethal viral disease vanish, a dire development that pushes Allison to tap into her extrasensory ability to foil a possible large-scale bioterrorism attack. Meanwhile, Scanlon prepares to pop the big question to Lynn (Tina DiJoseph), but Bridgette's visions indicate that their relationship could meet an ill-destined end
Allison teams up with a dead man to help solve a case, only to realize she's been hoodwinked.
Allison wrestles with a particularly disturbing dream, all while trying to figure out why a recently paroled convict is so intent on destroying her boss.
Allison believes that a paranoid schizophrenic girl was framed for her parents' murder years ago. Meanwhile, Bridgette suffers through the agony of her first crush on a guy friend.
With everyone caught up in the sensational trial of luscious young Gloria, accused of the murder of her 93 year old husband, Allison begins seeing the face of a man named Fred everywhere she goes.
After Allison is mugged, she decides to take charge by enrolling in self-defense classes. Also, Devalos investigates a teenager's rape and an undercover cop's possible murder, and the suspect may have very close ties to Scanlon.
It's 1993, and a pregnant Allison is about to marry Joe. But when she has a premonitory dream about one of the wedding guests, and Joe treats the incident with awkward disbelief, Allison gets a bad case of cold feet just as the wedding march starts to play.
Allison and her daughters dream of the same mysterious girl who may be linked to the bizarre serial murders of entire families. Joe and his boss find themselves at odds while working on a major project.
Allison bonds with the mysterious girl from her dreams who she now must protect when the serial killer eyes the girl as the next target.
After a neighbor is murdered, Allison's fears for her own family prompt her to install a high-tech talking burglar alarm, which she later suspects may be communicating with Marie. Also, Ariel meets a ghost who could help her get into the college of her choice.
A distressed Ariel begins to lose hours and then years of time in her life and must look to her future self to find out how to get back to the present.
When an animal rights activist working undercover at a farm goes missing, Allison befriends a pig that could hold the key to the woman's whereabouts. Also, Joe's special birthday gift from Marie leaves him wondering how she was able to obtain it.
When Allison's brain tumor resurfaces, its aftermath could have life-altering consequences for her friends and family, on the sixth season finale of MEDIUM.