After a car crashes into Joe’s Bar, Andy and Sullivan lead the team of firefighters as they work to rescue their fellow crewmates Ben and Pruitt, Grey Sloan doctors and interns, and bar patrons before the building comes crumbling down. The crossover continues on Grey's Anatomy S16E10 Help Me Through the Night (II).
The new Seattle fire chief is introduced to Station 19 and leaves the crew skeptical after his visit. Later, the firefighters are called to a department store fire caused by exploding fireworks, which triggers painful memories from Ben’s past and inspires him to pursue a new endeavor. Maya advocates for herself and her career, while Jack becomes more intertwined with an acquaintance; and Andy and Ryan have a heart-to-heart.
While Pruitt grieves a monumental loss, Andy refuses to do the same and, instead, throws herself into work. Meanwhile, the crew responds to a widespread carbon monoxide leak, and Sullivan makes a controversial choice for captain.
Ben and Jack mollify a group of homeless foster and biological siblings so they can help save a life, triggering memories from Jack’s past. Meanwhile, Maya pushes the team too hard and struggles to bring them together; and Pruitt threatens to take drastic action when refused a request.
In an effort to increase morale, Maya takes the crew on a team-building camping trip that doesn’t exactly go according to plan. Their bond is put to the test as they work to save first-time campers after a gruesome bear attack. Meanwhile, Pruitt takes steps to repair his relationship with Andy, and Sullivan goes to extreme lengths to find relief from the pain in his leg.
When a blizzard hits Seattle, Travis must take a difficult call and members of the crew are forced to face their truths. Meanwhile, Ben has rising suspicions about a colleague.
As Ben readies the new Physician Response Team truck for the field, his suspicions about Sullivan and the missing Fentanyl continue to grow. Meanwhile, Jack and Rigo try to look past their differences when they are forced to work together and fight a mysterious gas station fire; Dean and JJ try to work through their differing parenting styles; and Travis meets someone new.
The Station 19 crew responds to a drunk driver scene. Meanwhile, Dean receives advice from Pruitt on a difficult situation, and Sullivan seeks help from Dr. Amelia Shepherd.
When an Army veteran threatens to blow up a pawn shop, Sullivan reflects on his time as a Marine to deescalate the situation. Meanwhile, Vic and Dean try to reason with a man battling Alzheimer’s disease; and Pruitt takes a stand to honor fallen firefighters.
After some tense and traumatic experiences, the firefighters get a visit from a psychologist .
While at a lunch seeking Pruitt’s blessing for their relationship, Andy and Sullivan jump into action when ICE attempts to raid the restaurant. Meanwhile, Travis gets roped into an awkward lunch with Chief Dixon, Emmett and Emmett’s girlfriend; and Ben invites Grey-Sloan Memorial surgeons Owen Hunt, Teddy Altman and Jackson Avery to get a sneak peek of the new PRT vehicle.
The Station 19 crew battles a storage facility fire with growing complications, and Dr. Jackson Avery pops over from Grey Sloan and ends up collaborating with old pal Ben Warren.
Vic rallies the crew to pose for a calendar photo shoot that will support a good cause. Meanwhile, Emmett comes clean to Ben and Sullivan, and shows Andy a softer side.
Andy returns to work while she and Jack fight to save people trapped in a collapsing bowling alley. Meanwhile, Ben confronts Sullivan about his drug problem; and Maya’s mother, Katherine, pays Maya a visit.
Ben, Jackson and Emmett are put in a precarious and dangerous position with a potential victim. Andy’s search for more background on her family opens her eyes, and Vic and Travis are caught in the middle of a corruption scheme.
Andy becomes painfully suspicious of the circumstances surrounding her mother’s death and goes to her aunt looking for answers. Meanwhile, the members of the crew work to evacuate a doctor from Pac-North hospital and find themselves in a life-threatening situation; and Sullivan undergoes surgery for his chronic leg pain.