Dr. Max Goodwin and his heroic team of doctors and nurses continue their mission to provide exceptional healthcare amid opposition and personal crises.
Max works to find a new normal three months after the accident and the birth of his daughter. Kapoor grapples with the stigma of aging. Iggy has a successful day that inspires a life-changing idea. Reynolds deals with an unreliable new intern.
Max invokes a hospital-wide census in effort to get to know the staff of New Amsterdam on a deeper level. Reynolds takes a leap of faith that lands him in hot water, and Dr. Castro extends her treatment plan to more patients in the hospital.
Max takes a chance on a new assistant and goes toe-to-toe with the board on a new plan; Iggy struggles to figure out what is causing a unit-wide illness; Kapoor receives some shocking news.
When Iggy and Kapoor discover a patient might be suffering from lead poisoning, they are forced to take on the city. Meanwhile, Max's unsolicited attempts to help a patient backfires.
When Sharpe has a case that hits close to home, she and Max team up to make things right for the patient. Meanwhile, Iggy and Bloom are forced to make a tough call on a unique situation.
When a group of women on a retreat end up in the ED, Max gets some troubling information that could put a patient in jeopardy. Meanwhile, Sharpe and Kapoor work together to mend fences between two feuding sisters.
When Kapoor introduces a patient to Iggy's PTSD group, a creative treatment plan causes turmoil. Sharpe discovers a long-kept secret regarding a patient.
Sharpe lands in hot water when she goes out on a limb for a patient. Max's grief comes to a head. Bloom takes a major step in her recovery.
When an inmate comes in with an entirely preventable illness, Max, Sharpe, and Iggy head directly to the source - Rikers Island. Meanwhile, Bloom struggles with her recovery, and Reynolds gets news that could change his life.
With the hospital on lockdown after the Rikers patients escape, Sharpe and Max find themselves in a situation that could cost them their lives; Bloom must put aside her pain to help a patient; Iggy is forced to face his marriage's issues.
Max and Luna make friends in an unexpected place as Max struggles with the realities of being a single father. Meanwhile, Kapoor takes a big step in order to help his family.
Sharpe has an important realization that will affect her career. Meanwhile, Max and Reynolds take on uncharted waters when a young patient comes to New Amsterdam with symptoms of a heart attack.
The doctors stop at nothing to help their patients, following a shocking realization that prompts a change in the hospital. Meanwhile, Reynolds must make an important decision in his career.
Max races against the clock to rearrange the budget when faced with employees going unpaid, while Kapoor is presented with a device that's the future of medicine. Meanwhile, Iggy goes against the norms to prove a diagnosis and Bloom gets an unexpected visitor.
When tasked with turning the opioid epidemic around, Max shuts down the ED and proposes a massive change. Meanwhile, Sharpe goes great lengths to prove a point.
Max, Bloom and Reynolds frantically recount a patient's past encounter that could throw them into a massive lawsuit. Meanwhile, Iggy confronts a local middle school about its teaching policies, and Kapoor lets his superstitions take over.
Max searches for a solution to crowdfunding after his eye-opening appearance in a viral "Go Fund Me" video. Reynolds takes his last laps at the hospital while Kapoor helps a former pilot deal with his life as a paraplegic.
When multiple patients throughout the hospital begin to show similar, alarming symptoms, Sharpe and Bloom scramble to figure out the root of the issue. Iggy tries to create peace for a divorced couple in a dangerous situation and Kapoor experiences a flirtatious encounter. Meanwhile, Max meets a child with a rare muscular disease and desperately tries to get him into the only clinical trial in the country that could extend his life.